This product is offered at a very special price for our non-USA customers. You will see here, it is being offered by Amazon at £44.02 with shipping (at the time of writing) for the exact same product.
USA customers are advised to source from USA, where the product originates, as it will be less expensive for them
Ingredients - Source Naturals Advanced B12 Complex 5mg
Per Lozenge: Vitamin B12 5 mg (As methylcobalamin and adenosylcobalamin) Folate (as folic acid) 400 µg
Other ingredients: sorbitol, mannitol, natural cherry flavor, stearic acid, and magnesium stearate. Suitable for vegetarians and HYPOALLERGENIC: Contains no yeast, dairy, egg, gluten, corn, soy, or wheat. Contains no sugar, starch, salt, preservatives or artificial color, flavor or fragrance.
Directions - Source Naturals Advanced B12 Complex 5mg
General maintenance use: one lozenge daily dissolved in the mouth. Place tablet under the tongue and allow to dissolve slowly, altering its position to avoid prolonged contact with the same area.
Intensive use: up to 3 lozenges daily, dissolved in the mouth as above, or as recommended by a healthcare practitioner.
|Caution: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using these products.|
UPDATE - JANUARY 2016
(Further revised October 2017)
Vitamin B12 What is the Ideal Dose ?
We fully recommend the excellent and comprehensive book "Could it Be B12 ? An Epidemic of Misdiagnosis" by Sally M. Pacholok R.N BSN Jeffrey J. Stuart D.O. Extracts from which are included below. The book is available here
The danger of not taking high enough dosages - The case for classifying vitamin B12 as an essential supplement to try, for all of those with less than perfect health.
Conditions ranging from low energy, poor concentration, mental and emotional insecurity all the way through to chronic disease (be it hormonal, autoimmune, circulatory, brain or nervous system) may respond well.
Vitamin B12 has such a wide range of function in our physiology. It certainly is essential for health and even life itself. B12 has possibly the most complex and multi-staged route to absorption, conversion and finally assimilation into the cells, and this process often does not work properly resulting in deficiency. So it is not just a question of vegans becoming deficient, the majority of those who respond to B12 supplementation are meat, egg and fish eaters (so encompassing the main dietary sources of B12). B12 has several forms and conversion stages in the body. An example is Methycolbalamin; crucial for brain cell and nerve function and indeed ultimately survival. Another example is Adenosylcobalamin which is more involved in supporting the Krebs cycle (i.e. the production of ATP) for 80% of the bodies energy, oxygen utilisation and immune system health. B12 is also involved in protecting the blood from derangements that can lead to clot forming, and hence cardiac arrest (i.e. heart attack and stroke via its action on reducing homocysteine levels). High homocystein levels also contribute to arterial plaque that will stiffen the blood vessels and narrow them, further increasing the risk of strokes and heart attacks. Folic acid is one of the nutrients that converts homoysteine to a beneficial chemical, but cannot do its job properly without vitamin B12.
Mainstream/out of date medical practitioners only recognise B12 deficiency in relation to Pernicious anaemia and rely on the misleading Plasma B12 test. The established level for deficiency is also set too high. Certainly sub-clinical and long term effects of B12 deficiency are not taught to General Practitioners.
B12 was always known to be poorly absorbed if swallowed and some people would not respond at all to oral B12; therefore subcutaneous injections have traditionally been the favoured method of administration. However, with the arrival of sublingual lozenges that infuse some of the B12 directly into the bloodstream and also the use of the methylcolbalamin form of B12 within those lozenges that has been demonstrated to be far more efficiently absorbed and utilised, the need for injections has all but been eliminated.
The issues are:
Time taken to benefit.
Some people who have long term B12 deficiency can take months to fully respond to B12 supplementation, so unless they are aware of this and the time for symptom improvement is kept as short as possible many will give up taking the B12 before it has been been able to noticeably help the sufferer. The time taken to relieve symptoms can be reduced by taking high dose methylcolbalamin and/or adenosylcobalamin. These substances are non-toxic even at what would be considered high doses. 5 g has been administered in a clinical setting to treat cyanide poisoning. A 5 mg tablet is just 1,000th of that dose. Any excess methylcolbalamin and/or adenosylcobalamin for the daily needs will either be stored in the liver to top up the depleted reservoir or be eliminated from the body.
For those with long term issues such as psychiatric or mood disorders and also anyone suffering from neurological damage disorders of all kinds such as Parkinson's, Alzheimer's, Multiple Sclerosis, Motor Neurone disease etc. the need for high doses is especially urgent, in order to obtain some remission from their condition.
Vitamin B12 Deficiency Symptoms
Page 216-219 of the recommended book; Could it Be B12 ? An Epidemic of Misdiagnosis by Sally M. Pacholok R.N BSN Jeffrey J. Stuart D.O. details why testing is unreliable and suggests that clinical signs and symptoms should be the leading guide; this assesment is called the cobalamin deficiency risk score (CDR).
Please click here where you can view or download a .pdf file of the CDR assesment for yourself
Recently adenosylcobalamin has become available in a lozenge form and is well absorbed so we are recommending/supplying: Source Naturals Advanced B12 complex 5 mg 60 lozenges. Advanced B-12 Complex combines the two active, coenzymated forms of vitamin B-12 - methylcobalamin and adenosylcobalamin (dibencozide) - with folic acid. Note: adenosylcobalamin is involved in the krebs/ATP cycle, so this would also have some benefit vs. fatigue etc)
We have now permanently discontinued LEF 1mg Vitamin B12 60 Lozenges.
Specific medical conditions that are especially indicative of a B12 deficiency
Any neurological disorder
Any psychiatric disorder
Peripheral neuropathy (related to diabetes CIDP or other disorders)
Anaemia, any form
Optic neuritis or Optic atrophy
Congestive Heart failure
Type 1 diabetes
Chronic fatigue syndrome
About B12 Deficiency Tests
1/ The standard 'state sponsored' Doctor is not normally in the know concerning the vast array of conditions that are engendered by B12 deficiency. Usually they only relate pernicious anaemia to B12 deficiency.
2/ The definition of deficiency is set at a level that is too high. A high proportion of sufferers of B12 deficiency who respond well to B12 supplementation show a B12 blood plasma level of B12 that state sponsored doctors consider within normal range.
3/ Many who have B12 deficiency and have their conditions improved or completely resolved with B12 supplementation show adequate B12 levels in the blood plasma even by the more realistic criteria. This is due to the fact B12 has to be further metabolised and integrated into the cells. Failure to accomplish this is one of the common reasons for what we should call cellular B12 deficiency.
4/ A more reliable test is known as The Methylmalonic Acid test. This can be taken from the blood or more reliably from a urine sample. This test indicates if the body lacks B12 at the cellular level. However this test suffers from shortfalls. 1/ There is an error rate of about 20 %. This may be because just one sample is taken. If it could be taken daily for a period it would give a more reliable indication . Currently it costs around $200 per test (home test-urine sample sent to lab).
So bearing all this in mind, it is felt that vitamin B12 in the form of methylcolbalamin and adenosylcobalamin should be considered an essential supplement for all those who do not have radiant health. For those who have scored above 3 in the questionnaire higher doses are expedient. For those with neurological disorders or chronic illness even higher doses are suggested at level of at least 10 mg daily.
So, the epidemic of B12 deficiency and the above considerations places B12 forefront as one of the basic vitamin supplements. I would advise all of my clients to take this along with vitamin D (unless plenty of sun on exposed skin most days for at least 15 minutes) and vitamin C
The extreme results of prolonged vitamin B12 deficiency are brain damage and death, however death can also occur from heart attack or stroke due to B12 deficiency.